Madhav MENON Yale School of MedicineUnited States

I am an Associate professor and director of research in Kidney transplantation at Yale University School of Medicine. My research has focused on mechanisms of proteinuria and renal fibrosis underlying GWAS-identified genetic variants and non-HLA mismatches that also associate with allograft CKD. Our group has experience with human biopsy tissue and blood RNA/ DNA assays, PBMC evaluations, and morphometry applied to cohort studies. Using genotype-phenotype information from two prospective cohort studies we evaluated outcomes of APOL1-risk genotype transplant recipients and identified a novel immunologic role for APOL1 risk variants (CKD-associated variant in African-ancestry). Currently we are investigating this T-cell phenotype using novel Bac-transgenic mouse models, and its relevance to FSGS. My current research funding includes NIDDK for my work on SHROOM3, the role of AMPK signaling as a “switch” modulating podocyte survival between Minimal change disease and FSGS, from the Dept of Defense to study APOL1-variant Tcells.