Matthias Kretzler University Of Michigan Medical CenterUnited States

Dr. Kretzler is the Warner-Lambert/Parke-Davis Professor of Internal Medicine/Nephrology and Computational Medicine and Bioinformatics. He has 25 years of experience in integration of bioinformatics, molecular and clinical approaches in more than 400 collaborative studies on molecular analysis of renal disease. His research team has established a tract record on interdisciplinary data integration of large-scale data sets. He has initiated consortia for translational research in kidney disease including NEPTUNE, KPMP, CureGN, C-PROBE and ERCB. He focuses with his research team on the analysis of molecular mechanism of glomerular damage, defining regulatory networks in glomerular diseases in human cohorts and integrates them with genetic, proteomic, metabolomic, histological and clinical information. Key disease drivers along the genotype-phenotype continuum are used to identify novel disease predictors and targets molecular therapies in glomerular diseases from diabetic nephropathy to rare glomerular diseases.